Issue 16, 2011
From the journal:

Chemical Communications

Evaluation of Aβ fibrillization inhibitory effect by a PEG–peptide conjugate based on an Aβ peptide fragment with intramolecular FRET†

Toshihiko Sakurai,*a   Tomoki Iwasaki,a   Takashi Okuno,b   Yasushi Kawataa  and  Naoki Kisea  

* Corresponding authors

a Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-chou, Tottori 680-8552, Japan
E-mail: sakurai@bio.tottori-u.ac.jp
Fax: +81(0)857 31 5633
Tel: +81(0)857 31 5633

b Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
E-mail: okuno@pha.u-toyama.ac.jp
Fax: +81(0)76 434 7568

Abstract

A PEG–peptide conjugate based on an amyloid β peptide fragment was synthesized. The formed amyloid protofibril-like aggregates induced intramolecular FRET. It proved to be useful as a bioprobe to evaluate the inhibitory effect of organic molecules toward amyloid fibrillization.

Graphical abstract: Evaluation of Aβ fibrillization inhibitory effect by a PEG–peptide conjugate based on an Aβ peptide fragment with intramolecular FRET

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Article information

DOI
https://doi.org/10.1039/C0CC05668E
Article type
Communication
Submitted
20 Dec 2010
Accepted
02 Mar 2011
First published
17 Mar 2011

Chem. Commun., 2011,47, 4709-4711

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Evaluation of Aβ fibrillization inhibitory effect by a PEG–peptide conjugate based on an Aβ peptide fragment with intramolecular FRET

T. Sakurai, T. Iwasaki, T. Okuno, Y. Kawata and N. Kise, Chem. Commun., 2011, 47, 4709 DOI: 10.1039/C0CC05668E

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