Issue 29, 2011
From the journal:

Chemical Communications

Solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor†

Marc Vendrell,a   Gaddamanugu Gopi Krishna,b   Krishna Kanta Ghosh,b   Duanting Zhai,b   Jun-Seok Lee,bc   Qing Zhu,b   Yin Hoe Yau,d   Susana Geifman Shochat,d   Hyori Kim,e   Junho Chunge  and  Young-Tae Chang*ab  

* Corresponding authors

a Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Singapore

b Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, Singapore
E-mail: chmcyt@nus.edu.sg
Fax: +65 6779 1691
Tel: +65 6516 6774

c Life/Health Division, Integrated Omics Center, Korea Institute of Science and Technology (KIST), Seoul, Korea

d School of Biological Sciences, Nanyang Technological University, Singapore

e Department of Biochemistry and Molecular Biology, Seoul National University, School of Medicine, Korea

Abstract

The diversification of the BODIPY scaffold has been hindered by its controversial adaptability to solid-phase chemistry. Herein we report the first solid-phase synthesis of a BODIPY library in high purities. We screened the library against a set of proteins, identified an immunoglobulin fluorescent sensor (Ig Orange) and confirmed its binding by SPR experiments.

Graphical abstract: Solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor

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Article information

DOI
https://doi.org/10.1039/C1CC11774B
Article type
Communication
Submitted
29 Mar 2011
Accepted
06 Jun 2011
First published
24 Jun 2011

Chem. Commun., 2011,47, 8424-8426

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Solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor

M. Vendrell, G. G. Krishna, K. K. Ghosh, D. Zhai, J. Lee, Q. Zhu, Y. H. Yau, S. G. Shochat, H. Kim, J. Chung and Y. Chang, Chem. Commun., 2011, 47, 8424 DOI: 10.1039/C1CC11774B

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