Issue 29, 2011
From the journal:

Chemical Communications

Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene†

Alexey B. Kornev,a   Alexander S. Peregudov,b   Vyacheslav M. Martynenko,a   Jan Balzarini,c   Bart Hoorelbekec  and  Pavel A. Troshin*a  

* Corresponding authors

a IPCP RAS, Semenov Prospect 1, Chernogolovka, Russia
E-mail: troshin2003@inbox.ru
Fax: +7 496515-5420
Tel: +7 496522 1418

b INEOS RAS, Vavylova St. 28, B-334, Moscow, Russia

c Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000, Leuven, Belgium

Abstract

We report here a facile preparation of highly water-soluble derivatives C70[p-C6H4(CH2)nCOOH]8 (n = 2, 3) starting from readily available chlorinated [70]fullerene precursors C70Cl8 and C70Cl10. The synthesized fullerene derivatives showed pronounced antiviral activity in vitro, particularly against human immunodeficiency virus (HIV) and influenza A virus (subtypes H1N1 and H3N2).

Graphical abstract: Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene

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Article information

DOI
https://doi.org/10.1039/C1CC12209F
Article type
Communication
Submitted
17 Apr 2011
Accepted
23 May 2011
First published
10 Jun 2011

Chem. Commun., 2011,47, 8298-8300

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Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene

A. B. Kornev, A. S. Peregudov, V. M. Martynenko, J. Balzarini, B. Hoorelbeke and P. A. Troshin, Chem. Commun., 2011, 47, 8298 DOI: 10.1039/C1CC12209F

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