Issue 30, 2011
From the journal:

Chemical Communications

Self-assembling nanomicelles of a novel camptothecin prodrug engineered with a redox-responsive release mechanism†

Xue-Quan Li,a   Hui-Yun Wen,b   Hai-Qing Dong,b   Wei-Ming Xue,*a   Giovanni M. Pauletti,*c   Xiao-Jun Cai,b   Wen-Juan Xia,b   Donglu Shib  and  Yong-Yong Li*b  

* Corresponding authors

a School of Chemical Engineering, Northwest University, Xi'an 710069, China
E-mail: xuewm@nwu.edu.cn

b The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai 200092, China
E-mail: yongyong_li@tongji.edu.cn

c James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, USA
E-mail: PAULETGM@ucmail.uc.edu

Abstract

A novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed.

Graphical abstract: Self-assembling nanomicelles of a novel camptothecin prodrug engineered with a redox-responsive release mechanism

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Article information

DOI
https://doi.org/10.1039/C1CC12495A
Article type
Communication
Submitted
28 Apr 2011
Accepted
20 Jun 2011
First published
01 Jul 2011

Chem. Commun., 2011,47, 8647-8649

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Self-assembling nanomicelles of a novel camptothecin prodrug engineered with a redox-responsive release mechanism

X. Li, H. Wen, H. Dong, W. Xue, G. M. Pauletti, X. Cai, W. Xia, D. Shi and Y. Li, Chem. Commun., 2011, 47, 8647 DOI: 10.1039/C1CC12495A

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