Issue 28, 2011
From the journal:

Chemical Communications

Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors†

Jody L. Major Jourden,a   Kevin B. Daniela  and  Seth M. Cohena  

a Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA
E-mail: scohen@ucsd.edu
Fax: +1 858-822-5598
Tel: +1 858-822-5596

Abstract

A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors.

Graphical abstract: Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors

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Article information

DOI
https://doi.org/10.1039/C1CC12526E
Article type
Communication
Submitted
29 Apr 2011
Accepted
31 May 2011
First published
16 Jun 2011

Chem. Commun., 2011,47, 7968-7970

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Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors

J. L. M. Jourden, K. B. Daniel and S. M. Cohen, Chem. Commun., 2011, 47, 7968 DOI: 10.1039/C1CC12526E

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