Issue 44, 2011
From the journal:

Chemical Communications

Efficient RNA synthesis by in vitrotranscription of a triazole-modified DNA template†

Afaf H. El-Sagheerab  and  Tom Browna  

a School of Chemistry, University of Southampton, Highfield, Southampton, UK

b Chemistry Branch, Dept. of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez Canal University, Suez, Egypt

Abstract

A DNA strand containing a triazole phosphodiester mimic is an efficient template for in vitrotranscription. This is the first demonstration of transcription through a heavily modified DNA backbone linkage and it suggests that click-ligated DNA could be useful for the direct synthesis of biologically active RNA and proteins.

Graphical abstract: Efficient RNA synthesis by in vitrotranscription of a triazole-modified DNA template

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Article information

DOI
https://doi.org/10.1039/C1CC14316F
Article type
Communication
Submitted
18 Jul 2011
Accepted
19 Aug 2011
First published
30 Sep 2011

Chem. Commun., 2011,47, 12057-12058

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Efficient RNA synthesis by in vitrotranscription of a triazole-modified DNA template

A. H. El-Sagheer and T. Brown, Chem. Commun., 2011, 47, 12057 DOI: 10.1039/C1CC14316F

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