Issue 1, 2012
From the journal:

Chemical Communications

Decarboxylative benzylation and arylation of nitriles†‡

Antonio Recio, III,a   Jeffrey D. Heinzmana  and  Jon A. Tunge*a  

* Corresponding authors

a 2010 Malott Hall, 1251 Wescoe Hall Dr, Lawrence, KS USA
E-mail: tunge@ku.edu
Fax: 785-864-5396
Tel: 785-864-4136

Abstract

Decarboxylative benzylation of nitriles is achieved via coupling of metallated nitriles with Pd-π-benzyl complexes that are generated in situ from cyanoacetic benzyl esters. In addition, decarboxylative couplings of α,α-disubstituted 2-methylfuranyl cyanoacetates can lead to either decarboxylative arylation or benzylation depending on the reaction conditions.

Graphical abstract: Decarboxylative benzylation and arylation of nitriles

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Article information

DOI
https://doi.org/10.1039/C1CC16011G
Article type
Communication
Submitted
27 Sep 2011
Accepted
12 Oct 2011
First published
07 Nov 2011

Chem. Commun., 2012,48, 142-144

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Decarboxylative benzylation and arylation of nitriles

A. Recio, III, J. D. Heinzman and J. A. Tunge, Chem. Commun., 2012, 48, 142 DOI: 10.1039/C1CC16011G

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