Issue 8, 2012
From the journal:

Chemical Communications

Cellular uptake of a fluorescent vanadyl sulfonylcalix[4]arene†

Carl Redshaw,*a   Mark R. J. Elsegood,b   Joseph A. Wright,a   Hugo Baillie-Johnson,c   Takehiko Yamato,d   Stephen De Giovannie  and  Anja Mueller*e  

* Corresponding authors

a Energy Materials Laboratory, School of Chemistry, The University of East Anglia, Norwich, UK

b Chemistry Department, Loughborough University, Loughborough, Leicestershire, UK

c School of Biological Sciences, The University of East Anglia, Norwich, UK

d Department of Applied Chemistry, Faculty of Science and Engineering, Saga University, Honjo-machi, Saga-shi, Japan

e School of Pharmacy, The University of East Anglia, Norwich, UK

Abstract

Vanadyl bearing calix[4]arene ligands have undergone evaluation against several cell lines, and show varying degrees of toxicity. For vanadyl complexed to a sulfonylcalix[4]arene, monitoring of the strong blue fluorescence revealed slow uptake kinetics. The complex is exclusively found in the cytoplasm of the cells and uptake is not due to active endocytotic mechanisms.

Graphical abstract: Cellular uptake of a fluorescent vanadyl sulfonylcalix[4]arene

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Article information

DOI
https://doi.org/10.1039/C2CC16480A
Article type
Communication
Submitted
18 Oct 2011
Accepted
23 Nov 2011
First published
24 Nov 2011

Chem. Commun., 2012,48, 1129-1131

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Cellular uptake of a fluorescent vanadyl sulfonylcalix[4]arene

C. Redshaw, M. R. J. Elsegood, J. A. Wright, H. Baillie-Johnson, T. Yamato, S. D. Giovanni and A. Mueller, Chem. Commun., 2012, 48, 1129 DOI: 10.1039/C2CC16480A

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