Issue 53, 2012
From the journal:

Chemical Communications

Cellular uptake studies of two hexanuclear, carboxylate bridged, zinc ring structures using fluorescence microscopy†

Carl Redshaw,*a   Mark R. J. Elsegood,b   Josef W. A. Frese,b   Shane Ashby,a   Yimin Chaoa  and  Anja Mueller*c  

* Corresponding authors

a School of Chemistry, University of East Anglia, Norwich, UK
E-mail: carl.redshaw@uea.ac.uk

b Chemistry Department, Loughborough University, Loughborough, Leicestershire, UK

c School of Pharmacy, University of East Anglia, Norwich, UK
E-mail: anja.mueller@uea.ac.uk

Abstract

Two hexanuclear zinc complexes have been structurally characterized, and evaluation against several cells showed selective toxicity. Cellular uptake revealed a non-specific process, resulting in accumulation within the cell cytoplasm.

Graphical abstract: Cellular uptake studies of two hexanuclear, carboxylate bridged, zinc ring structures using fluorescence microscopy

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Article information

DOI
https://doi.org/10.1039/C2CC32060F
Article type
Communication
Submitted
21 Mar 2012
Accepted
13 Apr 2012
First published
16 Apr 2012

Chem. Commun., 2012,48, 6627-6629

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Cellular uptake studies of two hexanuclear, carboxylate bridged, zinc ring structures using fluorescence microscopy

C. Redshaw, M. R. J. Elsegood, J. W. A. Frese, S. Ashby, Y. Chao and A. Mueller, Chem. Commun., 2012, 48, 6627 DOI: 10.1039/C2CC32060F

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