Issue 59, 2012
From the journal:

Chemical Communications

Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride†

Nicola Kielland,‡a   Marc Vendrell,‡b   Rodolfo Lavilla*cd  and  Young-Tae Chang*be  

* Corresponding authors

a Institute for Biomedical Research, Barcelona Science Park, Spain.

b Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, A*STAR, Singapore.

c Barcelona Science Park, University of Barcelona, Spain.

d Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Spain
E-mail: rlavilla@pcb.ub.es
Fax: +34 4021896
Tel: +34 4037126

e Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, Singapore
E-mail: chmcyt@nus.edu.sg
Fax: +65 6779 1691
Tel: +65 6516 6774

Abstract

Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging intracellular histamine in live basophils and macrophages. Histamine Blue is a fluorescent mesoionic acid fluoride that turns on upon reaction with histamine. The selective response of Histamine Blue enabled the visualization of intracellular histamine under different physiological conditions.

Graphical abstract: Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

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Article information

DOI
https://doi.org/10.1039/C2CC32292G
Article type
Communication
Submitted
30 Mar 2012
Accepted
29 May 2012
First published
30 May 2012

Chem. Commun., 2012,48, 7401-7403

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Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

N. Kielland, M. Vendrell, R. Lavilla and Y. Chang, Chem. Commun., 2012, 48, 7401 DOI: 10.1039/C2CC32292G

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