Issue 58, 2012
From the journal:

Chemical Communications

Efficient palladium-catalyzed synthesis of substituted indoles employing a new (silanyloxyphenyl)phosphine ligand†

Christopher B. Lavery,a   Robert McDonaldb  and  Mark Stradiotto*a  

* Corresponding authors

a Department of Chemistry, Dalhousie University, 6274 Coburg Road, P.O. Box 15000, Halifax, Nova Scotia, Canada
E-mail: mark.stradiotto@dal.ca
Fax: 1 902 494 1310
Tel: 1 902 494 7190

b X-Ray Crystallography Laboratory, Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

Abstract

The new and easily prepared OTips-DalPhos ligand (L1) offers broad substrate scope at relatively low loadings in the palladium-catalyzed C–N cross-coupling/cyclization of o-alkynylhalo(hetero)arenes with primary amines, affording indoles and related heterocyclic derivatives in high yield.

Graphical abstract: Efficient palladium-catalyzed synthesis of substituted indoles employing a new (silanyloxyphenyl)phosphine ligand

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Article information

DOI
https://doi.org/10.1039/C2CC33071G
Article type
Communication
Submitted
28 Apr 2012
Accepted
25 May 2012
First published
18 Jun 2012

Chem. Commun., 2012,48, 7277-7279

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Efficient palladium-catalyzed synthesis of substituted indoles employing a new (silanyloxyphenyl)phosphine ligand

C. B. Lavery, R. McDonald and M. Stradiotto, Chem. Commun., 2012, 48, 7277 DOI: 10.1039/C2CC33071G

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