Issue 67, 2012
From the journal:

Chemical Communications

Surface-modified protein nanospheres as potential antiviral agents†

Dana Baram-Pinto,ab   Sourabh Shukla,a   Michal Richman,c   Aharon Gedanken,a   Shai Rahimipour*c  and  Ronit Sarid*b  

* Corresponding authors

a Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 52900, Israel

b The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
E-mail: saridr@biu.ac.il
Fax: +972 3 7384058

c Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel
E-mail: rahimis@biu.ac.il
Fax: +972 3 7384 053

Abstract

A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.

Graphical abstract: Surface-modified protein nanospheres as potential antiviral agents

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Article information

DOI
https://doi.org/10.1039/C2CC33448H
Article type
Communication
Submitted
13 May 2012
Accepted
27 Jun 2012
First published
27 Jun 2012

Chem. Commun., 2012,48, 8359-8361

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Surface-modified protein nanospheres as potential antiviral agents

D. Baram-Pinto, S. Shukla, M. Richman, A. Gedanken, S. Rahimipour and R. Sarid, Chem. Commun., 2012, 48, 8359 DOI: 10.1039/C2CC33448H

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