Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system

Stefano D'Errico; Giorgia Oliviero; Jussara Amato; Nicola Borbone; Vincenzo Cerullo; Akseli Hemminki; Vincenzo Piccialli; Sabrina Zaccaria; Luciano Mayol; Gennaro Piccialli

doi:10.1039/C2CC33511E

Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system†

Stefano D'Errico,^a Giorgia Oliviero,*^a Jussara Amato,^a Nicola Borbone,^a Vincenzo Cerullo,^b Akseli Hemminki,^c Vincenzo Piccialli,^d Sabrina Zaccaria,^d Luciano Mayol^a and Gennaro Piccialli^a

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* Corresponding authors

^a Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, Napoli, Italy
E-mail: golivier@unina.it

^b Laboratory of Immunovirotherapy, Division of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

^c Cancer Gene Therapy Group, University of Helsinki & Helsinki University Central Hospital, Haartmaninkatu 8, Helsinki, Finland

^d Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Via Cintia 21, Napoli, Italy

Abstract

A small collection of ring-expanded nucleosides (RENs), containing the unprecedented bis-alkylated imidazo[4,5-d][1,2,6]oxadiazepine heterocyclic ring system, has been synthesized through a new general approach. Results of preliminary cytotoxicity tests on breast (MCF-7) and lung (A549) cancer cell lines are also reported.

Chemical Communications

Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system†

Abstract

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Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system

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