Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle

Chun-Yi Sun; Chao Qin; Xin-Long Wang; Guang-Sheng Yang; Kui-Zhan Shao; Ya-Qian Lan; Zhong-Min Su; Peng Huang; Chun-Gang Wang; En-Bo Wang

doi:10.1039/C2DT30357D

Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle†

Chun-Yi Sun,^a Chao Qin,^a Xin-Long Wang,*^a Guang-Sheng Yang,^a Kui-Zhan Shao,^a Ya-Qian Lan,^a Zhong-Min Su,*^a Peng Huang,^a Chun-Gang Wang^a and En-Bo Wang^a

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^a Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education Department of Chemistry, Northeast Normal University, Changchun, China
E-mail: zmsu@nenu.edu.cn

Abstract

Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer.

Dalton Transactions

Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle†

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Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle

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