Issue 26, 2012
From the journal:

Organic & Biomolecular Chemistry

Rubesanolides C–E: abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity†

Juan Zou,ab   Lutai Pan,*a   Qiji Li,a   Jianxin Pu,b   Ping Yao,c   Min Zhu,d   Jeffrey A. Banas,d   Hongjie Zhang*e  and  Handong Sunb  

* Corresponding authors

a Guiyang College of Traditional Chinese Medicine, Guiyang 550002, Guizhou, China
E-mail: ltpan@yahoo.cn
Fax: +86 852 3840100
Tel: +86 852 3840100

b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China

c Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA

d Dows Institute for Dental Research, College of Dentistry, The University of Iowa, 418 Dental Science N, Iowa City, Iowa 52242, USA

e School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong
E-mail: zhanghj@hkbu.edu.hk
Fax: +852 3411 2461
Tel: +852 3411 2956

Abstract

Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C–E (1–3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.

Graphical abstract: Rubesanolides C–E: abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity

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Article information

DOI
https://doi.org/10.1039/C2OB25192B
Article type
Paper
Submitted
26 Jan 2012
Accepted
13 Apr 2012
First published
16 Apr 2012

Org. Biomol. Chem., 2012,10, 5039-5044

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Rubesanolides C–E: abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity

J. Zou, L. Pan, Q. Li, J. Pu, P. Yao, M. Zhu, J. A. Banas, H. Zhang and H. Sun, Org. Biomol. Chem., 2012, 10, 5039 DOI: 10.1039/C2OB25192B

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