Issue 43, 2012
From the journal:

Organic & Biomolecular Chemistry

Cu(ii)-promoted three-component coupling sequence for the efficient synthesis of substituted quinolines†

Fuhong Xiao,a   Wen Chen,a   Yunfeng Liaoa  and  Guo-Jun Deng*a  

* Corresponding authors

a Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, China
E-mail: gjdeng@xtu.edu.cn
Fax: (+86)-731-58292251
Tel: (+86)-731-58298601

Abstract

The copper-promoted three-component coupling sequence for substituted quinoline formation from aldehydes, anilines and acetone is described. Various 2-arylquinolines were selectively obtained in good yields under mild conditions. The reaction tolerated a wide range of functionalities.

Graphical abstract: Cu(ii)-promoted three-component coupling sequence for the efficient synthesis of substituted quinolines

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Article information

DOI
https://doi.org/10.1039/C2OB26484F
Article type
Communication
Submitted
30 Jul 2012
Accepted
10 Sep 2012
First published
12 Sep 2012

Org. Biomol. Chem., 2012,10, 8593-8596

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Cu(II)-promoted three-component coupling sequence for the efficient synthesis of substituted quinolines

F. Xiao, W. Chen, Y. Liao and G. Deng, Org. Biomol. Chem., 2012, 10, 8593 DOI: 10.1039/C2OB26484F

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