Doxorubicin is a photocatalyst for the generation of H2O2

Krzysztof Nawara; Pawel Krysinski; G. J. Blanchard

doi:10.1039/C2RA20323E

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Doxorubicin is a photocatalyst for the generation of H₂O₂†

Krzysztof Nawara,^ab Pawel Krysinski^b and G. J. Blanchard*^a

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* Corresponding authors

^a Michigan State University, Department of Chemistry, East Lansing, MI, USA
E-mail: blanchard@chemistry.msu.edu
Tel: +1 517-355-9715 x224

^b University of Warsaw, Department of Chemistry, Pasteura 1, Warsaw, Poland

Abstract

We have investigated the photoreactivity of the chemotherapeutic agent doxorubicin. We demonstrate the ability of this compound to generate H₂O₂ catalytically as a result of auto-oxidation of its photoreduced form. H₂O₂ may accumulate in toxic levels in pharmaceutical preparations.

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Article information

DOI: https://doi.org/10.1039/C2RA20323E
Article type: Communication
Submitted: 21 Feb 2012
Accepted: 09 Mar 2012
First published: 09 Mar 2012

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RSC Adv., 2012,2, 4059-4061

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Doxorubicin is a photocatalyst for the generation of H₂O₂

K. Nawara, P. Krysinski and G. J. Blanchard, RSC Adv., 2012, 2, 4059 DOI: 10.1039/C2RA20323E

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