Issue 10, 2013
From the journal:

Chemical Communications

Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids†‡

Dnyaneshwar B. Gophanea  and  Snorri Th. Sigurdsson*a  

* Corresponding authors

a University of Iceland, Department of Chemistry, Science Institute, Dunhaga 3, 107 Reykjavik, Iceland
E-mail: snorrisi@hi.is

Abstract

Nucleosides spin-labelled with isoindoline-derived benzimidazole (ImU) and benzoxazole (OxU) moieties were synthesized and incorporated into DNA oligonucleotides. Both labels display limited mobility in duplex DNA but ImU was less mobile, which was attributed to an intramolecular hydrogen bond between the N–H of the imidazole and O4 of the uracil nucleobase.

Graphical abstract: Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

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Article information

DOI
https://doi.org/10.1039/C2CC36389E
Article type
Communication
Submitted
02 Sep 2012
Accepted
21 Nov 2012
First published
19 Dec 2012

Chem. Commun., 2013,49, 999-1001

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Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

D. B. Gophane and S. Th. Sigurdsson, Chem. Commun., 2013, 49, 999 DOI: 10.1039/C2CC36389E

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