Issue 10, 2013
From the journal:

Chemical Communications

Investigation of Zr(iv) and 89Zr(iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging†

François Guérard,a   Yong-Sok Lee,b   Raphaël Tripier,c   Lawrence P. Szajek,d   Jeffrey R. Deschampse  and  Martin W. Brechbiel*a  

* Corresponding authors

a Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, NCI, NIH, Bethesda, Maryland 20892, USA
E-mail: martinwb@mail.nih.gov
Fax: +1 301-402-1923
Tel: +1 301-496-0591

b Center for Molecular Modeling, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA

c CNRS, UMR 6521, Université de Brest, Laboratoire de Chimie, Electrochimie Moléculaires et Chimie Analytique, 6 Avenue Victor Le Gorgeu, 29200 Brest, France

d Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA

e Center for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC,, USA

Abstract

Single crystal X-ray diffraction shows that Zr(IV) forms an octa-coordinated complex with 4 bidentate hydroxamates whose solution structures were investigated by utilizing density functional theory at the level of B3LYP/DGDZVP. Stability constants obtained by potentiometry were in accordance with the tendency observed when radiolabeling with 89Zr.

Graphical abstract: Investigation of Zr(iv) and 89Zr(iv) complexation with hydroxamates : progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging

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Article information

DOI
https://doi.org/10.1039/C2CC37549D
Article type
Communication
Submitted
16 Oct 2012
Accepted
11 Dec 2012
First published
12 Dec 2012

Chem. Commun., 2013,49, 1002-1004

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Investigation of Zr(IV) and 89Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging

F. Guérard, Y. Lee, R. Tripier, L. P. Szajek, J. R. Deschamps and M. W. Brechbiel, Chem. Commun., 2013, 49, 1002 DOI: 10.1039/C2CC37549D

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