Issue 7, 2013
From the journal:

Chemical Communications

Highly regioselective synthesis of fused seven-membered rings through copper-catalyzed cross-coupling†

Peng Sang,a   Ming Yu,a   Hangfei Tu,a   Jianwei Zouab  and  Yuhong Zhang*ac  

* Corresponding authors

a Department of Chemistry, Zhejiang University, Hangzhou 310027, China
E-mail: yhzhang@zju.edu.cn

b Ningbo Institute of Technology, Zhejiang University, Ningbo 315104, China

c State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China

Abstract

A highly efficient protocol of copper catalysis for the one-pot synthesis of fused dibenzo[b,f][1,4]oxazepines is reported. The transformation involves a Smiles rearrangement, leading to the completely different regioselectivity from the classical cross-coupling. The easy reaction of aryl chlorides as substrates enhances the practical application of the methodology.

Graphical abstract: Highly regioselective synthesis of fused seven-membered rings through copper-catalyzed cross-coupling

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Article information

DOI
https://doi.org/10.1039/C2CC37891D
Article type
Communication
Submitted
31 Oct 2012
Accepted
30 Nov 2012
First published
03 Dec 2012

Chem. Commun., 2013,49, 701-703

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Highly regioselective synthesis of fused seven-membered rings through copper-catalyzed cross-coupling

P. Sang, M. Yu, H. Tu, J. Zou and Y. Zhang, Chem. Commun., 2013, 49, 701 DOI: 10.1039/C2CC37891D

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