Issue 24, 2013
From the journal:

Chemical Communications

Branched peptideboronic acids (BPBAs): a novel mode of binding towards RNA†

Wenyu Zhang,‡a   David I. Bryson,‡a   Jason B. Crumpton,‡a   Jessica Wynna  and  Webster L. Santos*a  

* Corresponding authors

a Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, USA
E-mail: santosw@vt.edu
Fax: +1 540 231 3255
Tel: +1 540 231 5041

Abstract

We report branched peptideboronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.

Graphical abstract: Branched peptideboronic acids (BPBAs): a novel mode of binding towards RNA

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Article information

DOI
https://doi.org/10.1039/C3CC00243H
Article type
Communication
Submitted
10 Jan 2013
Accepted
07 Feb 2013
First published
07 Feb 2013
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2013,49, 2436-2438

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Branched peptideboronic acids (BPBAs): a novel mode of binding towards RNA

W. Zhang, D. I. Bryson, J. B. Crumpton, J. Wynn and W. L. Santos, Chem. Commun., 2013, 49, 2436 DOI: 10.1039/C3CC00243H

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