Issue 42, 2013
From the journal:

Chemical Communications

Micellar nanoparticle formation via electrostatic interactions for delivering multinuclear platinum(ii) drugs†

Haihua Xiao,a   Jared F. Stefanick,a   Xiaoyu Jia,b   Xiabin Jing,c   Tanyel Kiziltepe,ad   Yu Zhang*e  and  Basar Bilgicer*adf  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, USA
E-mail: bbilgicer@nd.edu

b State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, PR China

c State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China

d Advanced Diagnostics and Therpeutics, University of Notre Dame, Notre Dame, IN, USA

e National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, PR China
E-mail: zhangy259@nenu.edu.cn

f Mike and Josie Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA

Abstract

Nanoparticles formed via electrostatic interactions between methoxy-polyethylene glycol-block-poly(glutamic acid) (MPEG-PGA) and a multinuclear platinum(II) drug, di-cisPt, exhibit efficient platinum loading, improved cellular uptake, in vitro cytotoxicity, and enhanced in vivo efficacy.

Graphical abstract: Micellar nanoparticle formation via electrostatic interactions for delivering multinuclear platinum(ii) drugs

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Article information

DOI
https://doi.org/10.1039/C3CC39119A
Article type
Communication
Submitted
20 Dec 2012
Accepted
25 Mar 2013
First published
26 Mar 2013

Chem. Commun., 2013,49, 4809-4811

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Micellar nanoparticle formation via electrostatic interactions for delivering multinuclear platinum(II) drugs

H. Xiao, J. F. Stefanick, X. Jia, X. Jing, T. Kiziltepe, Y. Zhang and B. Bilgicer, Chem. Commun., 2013, 49, 4809 DOI: 10.1039/C3CC39119A

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