Issue 31, 2013
From the journal:

Chemical Communications

Label-free biosensing with single-molecule force spectroscopy†

Gang Wei,*a   Sascha Steckbeck,a   Susan Köppena  and  Lucio Colombi Ciacchi*ab  

* Corresponding authors

a Hybrid Materials Interfaces Group, Faculty of Production Engineering, University of Bremen, D-28359 Bremen, Germany
E-mail: wei@uni-bremen.de, colombi@hmi.uni-bremen.de

b Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM, D-28359 Bremen, Germany

Abstract

We demonstrate here a novel single-molecule, label-free bioanalytical system capable of sensing the presence of specific ssDNA oligomer sequences and proteins with high selectivity and sensitivity. An ssDNA concentration of 1 nM and a Lyz concentration of 0.65 nM could be detected.

Graphical abstract: Label-free biosensing with single-molecule force spectroscopy

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Article information

DOI
https://doi.org/10.1039/C3CC40506K
Article type
Communication
Submitted
21 Jan 2013
Accepted
01 Mar 2013
First published
01 Mar 2013

Chem. Commun., 2013,49, 3239-3241

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Label-free biosensing with single-molecule force spectroscopy

G. Wei, S. Steckbeck, S. Köppen and L. Colombi Ciacchi, Chem. Commun., 2013, 49, 3239 DOI: 10.1039/C3CC40506K

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