Issue 38, 2013
From the journal:

Chemical Communications

Protein-coated nanofibers for promotion of T cell activity†

Taehoon Kim,a   Hyojin Lee,b   Yongju Kim,a   Jwa-Min Namb  and  Myongsoo Lee*a  

* Corresponding authors

a The State Key Lab of Supramolecular Structure and Materials, Department of Chemistry, Jilin University, Changchun 130012, P. R. China
E-mail: mslee@jlu.edu.cn

b Department of Chemistry, Seoul National University, Seoul 151-747, Korea

Abstract

We have demonstrated that stable Concanavalin A (Con A)-coated supramolecular nanofibers can be constructed by complexation of self-assembled mannose nanofibers with Con A. The extended multivalent Con A nanofibers bind strongly to T cell surfaces and promote T cell activation.

Graphical abstract: Protein-coated nanofibers for promotion of T cell activity

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Article information

DOI
https://doi.org/10.1039/C3CC41215F
Article type
Communication
Submitted
15 Feb 2013
Accepted
22 Mar 2013
First published
22 Mar 2013

Chem. Commun., 2013,49, 3949-3951

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Protein-coated nanofibers for promotion of T cell activity

T. Kim, H. Lee, Y. Kim, J. Nam and M. Lee, Chem. Commun., 2013, 49, 3949 DOI: 10.1039/C3CC41215F

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