CuBr for KA2 reaction: en route to propargylic amines bearing a quaternary carbon center

Xinjun Tang; Jinqiang Kuang; Shengming Ma

doi:10.1039/C3CC45301D

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CuBr for KA² reaction: en route to propargylic amines bearing a quaternary carbon center†

Xinjun Tang,^a Jinqiang Kuang^a and Shengming Ma*^ab

Author affiliations

* Corresponding authors

^a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. China

^b Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China
E-mail: masm@sioc.ac.cn
Fax: +86-21-6260-9305

Abstract

A highly efficient CuBr-catalyzed coupling of ketones, amines and alkynes (KA²) forming propargylic amines bearing a quaternary carbon center with the broadest scope so far has been developed.

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Article information

DOI: https://doi.org/10.1039/C3CC45301D
Article type: Communication
Submitted: 14 Jul 2013
Accepted: 31 Jul 2013
First published: 01 Aug 2013

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Chem. Commun., 2013,49, 8976-8978

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CuBr for KA² reaction: en route to propargylic amines bearing a quaternary carbon center

X. Tang, J. Kuang and S. Ma, Chem. Commun., 2013, 49, 8976 DOI: 10.1039/C3CC45301D

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