The synthesis of unnatural pyrrolizidines has been studied using a multicomponent-domino process involving proline or 4-hydroxyproline esters, an aldehyde and a dipolarophile. The formation of the iminium salt promotes the 1,3-dipolar cycloaddition affording highly substituted pyrrolizidines under mild conditions and high regio- and diastereoselectivities.
J. Mancebo-Aracil, C. Nájera and J. M. Sansano, Chem. Commun., 2013, 49, 11218 DOI: 10.1039/C3CC47184E
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