Issue 8, 2013
From the journal:

Nanoscale

Shell crosslinked knedel-like nanoparticles for delivery of cisplatin: effects of crosslinking†

Fuwu Zhang,a   Mahmoud Elsabahy,*ab   Shiyi Zhang,ac   Lily Yun Lin,‡a   Jiong Zoua  and  Karen L. Wooley*a  

* Corresponding authors

a Department of Chemistry and Department of Chemical Engineering, Laboratory for Synthetic – Biologic Interactions, Texas A&M University, P.O. Box 30012, 3255 TAMU, College Station, Texas 77842-3012, USA
E-mail: mahmoud.elsabahy@chem.tamu.edu, wooley@chem.tamu.edu
Fax: +1 979 862 1137
Tel: +1 979 845 4077

b Department of Pharmaceutics, Faculty of Pharmacy, Assiut International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Assiut, Egypt

c Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, USA

Abstract

Polymeric micelles and shell crosslinked knedel-like (SCK) nanoparticles were loaded with up to 48% (w/w) cisplatin. These spherical cisplatin-loaded nanoparticles displayed sustained platinum release over 5 days in PBS, enhanced stability over free cisplatin in aqueous milieu, and significant antitumor activity in vitro against two cancer cell lines.

Graphical abstract: Shell crosslinked knedel-like nanoparticles for delivery of cisplatin: effects of crosslinking

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Article information

DOI
https://doi.org/10.1039/C3NR34320K
Article type
Communication
Submitted
27 Dec 2012
Accepted
02 Mar 2013
First published
11 Mar 2013

Nanoscale, 2013,5, 3220-3225

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Shell crosslinked knedel-like nanoparticles for delivery of cisplatin: effects of crosslinking

F. Zhang, M. Elsabahy, S. Zhang, L. Y. Lin, J. Zou and K. L. Wooley, Nanoscale, 2013, 5, 3220 DOI: 10.1039/C3NR34320K

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