Issue 30, 2013
From the journal:

RSC Advances

Antineoplastic tropolone derivatives as useful biomarkers: fluorescence enhancement upon binding to biological targets†

Rosa Tormosa  and  Francisco Bosca*b  

* Corresponding authors

a Departamento de Química (UPV), Universitat Politecnica de Valencia, Camino de Vera s/n, 46022 Valencia, Spain
E-mail: rtormos@qim.upv.es
Tel: 34 963873427

b Instituto Universitario Mixto de Tecnologia Quimica (UPV-CSIC), Universitat Politecnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia, Spain
E-mail: fbosca@itq.upv.es
Fax: 34 963877815
Tel: 34 963877809

Abstract

It has been observed for the first time that the binding of tropolone derivatives to human serum albumin (HSA) produce a high fluorescence promotion. Important evidence of the immobilization of these drugs into the protein has been found by UV-vis spectrometry. Moreover, the literature contradictions about the interactions between colchicine and HSA have been unequivocally resolved.

Graphical abstract: Antineoplastic tropolone derivatives as useful biomarkers: fluorescence enhancement upon binding to biological targets

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Article information

DOI
https://doi.org/10.1039/C3RA42122H
Article type
Communication
Submitted
29 Apr 2013
Accepted
24 May 2013
First published
30 May 2013

RSC Adv., 2013,3, 12031-12034

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Antineoplastic tropolone derivatives as useful biomarkers: fluorescence enhancement upon binding to biological targets

R. Tormos and F. Bosca, RSC Adv., 2013, 3, 12031 DOI: 10.1039/C3RA42122H

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