Issue 43, 2013
From the journal:

RSC Advances

Novel self-assembled lithocholic acidnanoparticles for drug delivery in cancer†

Sumersing Patil,ab   Sohan Patil,‡a   Suhas Gawali,‡a   Shrikant Shende,a   Shraddha Jadhava  and  Sudipta Basu*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Science Education and Research (IISER)-Pune, Pune, Maharashtra, India
E-mail: sudipta.basu@iiserpune.ac.in

b Institute of Bioinformatics and Biotechnology (IBB), University of Pune, Pune, Maharashtra, India

Abstract

Novel versatile self-assembled nanoparticles were developed from biocompatible, biodegradable lithocholic acid derivatives. These nanoparticles can incorporate different cytotoxic drugs (paclitaxel and doxorubicin) and PI3K signalling inhibitor (PI103). Drugs were released from the nanoparticles in a slow, sustained manner at acidic pH. The drug loaded nanoparticles were internalized through lysosomal compartments and induced cell death in HeLa cervical cancer cells.

Graphical abstract: Novel self-assembled lithocholic acid nanoparticles for drug delivery in cancer

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Article information

DOI
https://doi.org/10.1039/C3RA42994F
Article type
Communication
Submitted
15 Jun 2013
Accepted
15 Aug 2013
First published
16 Aug 2013

RSC Adv., 2013,3, 19760-19764

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Novel self-assembled lithocholic acid nanoparticles for drug delivery in cancer

S. Patil, S. Patil, S. Gawali, S. Shende, S. Jadhav and S. Basu, RSC Adv., 2013, 3, 19760 DOI: 10.1039/C3RA42994F

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