Issue 23, 2014
From the journal:

Chemical Communications

Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor†

Sai Pradeep Velagapudiab  and  Matthew D. Disney*a  

* Corresponding authors

a Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #3A1, Jupiter, Florida 33458, USA
E-mail: Disney@scripps.edu

b Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York 14260, USA

Abstract

The RNA motifs that bind guanidinylated kanamycin A (G Kan A) and guanidinylated neomycin B (G Neo B) were identified via two-dimensional combinatorial screening (2DCS). The results of these studies enabled the “bottom-up” design of a small molecule inhibitor of oncogenic microRNA-10b.

Graphical abstract: Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor

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Article information

DOI
https://doi.org/10.1039/C3CC00173C
Article type
Communication
Submitted
08 Jan 2013
Accepted
19 Dec 2013
First published
17 Jan 2014

Chem. Commun., 2014,50, 3027-3029

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Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor

S. P. Velagapudi and M. D. Disney, Chem. Commun., 2014, 50, 3027 DOI: 10.1039/C3CC00173C

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