Issue 3, 2014
From the journal:

Chemical Communications

A new type of DNA “light-switch”: a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA†

Erin Wachter,a   Brock S. Howerton,a   Emily C. Hall,a   Sean Parkina  and  Edith C. Glazer*a  

* Corresponding authors

a Department of Chemistry, University of Kentucky, Lexington KY 40506, USA
E-mail: ec.glazer@uky.edu
Fax: +1 859-323-1069
Tel: +1 859-257-2198

Abstract

Ru(bpy)2dppz, a well studied “light-switch” metal complex, transforms into a photochemical “light-switch” and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.

Graphical abstract: A new type of DNA “light-switch”: a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

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Article information

DOI
https://doi.org/10.1039/C3CC47269H
Article type
Communication
Submitted
23 Sep 2013
Accepted
01 Nov 2013
First published
05 Nov 2013

Chem. Commun., 2014,50, 311-313

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A new type of DNA “light-switch”: a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

E. Wachter, B. S. Howerton, E. C. Hall, S. Parkin and E. C. Glazer, Chem. Commun., 2014, 50, 311 DOI: 10.1039/C3CC47269H

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