Highly enantioselective hydrogenation of a variety of 2-substituted-2-alkenols has been achieved using a ChenPhos–Rh complex as catalyst, giving ≥99% ee for most substrates. Optically active antifungal agent amorolfine was first synthesised using hydrogenation as the key step.
Q. Wang, X. Liu, X. Liu, B. Li, H. Nie, S. Zhang and W. Chen, Chem. Commun., 2014, 50, 978 DOI: 10.1039/C3CC47727D
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