A novel acetyl chloride-mediated cascade transformation involving three components (benzyl carbamate, ethyl glyoxylate and arene nucleophiles) is reported. Aryl orthogonally protected α-amino acids are obtained in a one pot cascade, using a mild AcOH–AcCl system, via a critical autocatalytic dehydration-activation step ensuring an original and efficient Friedel–Crafts orchestration.
S. P. Roche, S. S. Samanta and M. M. J. Gosselin, Chem. Commun., 2014, 50, 2632 DOI: 10.1039/C3CC48884E
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