Issue 43, 2014
From the journal:

Chemical Communications

Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines†

Danny C. Lenstra,a   Floris P. J. T. Rutjesa  and  Jasmin Mecinović*a  

* Corresponding authors

a Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
E-mail: j.mecinovic@science.ru.nl
Fax: +31 24 3653393
Tel: +31 24 3652381

Abstract

Unactivated carboxylic acids and amines undergo organocatalytic Ph3P/CCl4-mediated amide bond formation by employing in situ reduction of triphenylphosphine oxide to triphenylphosphine in the presence of diethoxymethylsilane and bis(4-nitrophenyl)phosphate.

Graphical abstract: Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines

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Article information

DOI
https://doi.org/10.1039/C4CC01861C
Article type
Communication
Submitted
12 Mar 2014
Accepted
08 Apr 2014
First published
08 Apr 2014

Chem. Commun., 2014,50, 5763-5766

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Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines

D. C. Lenstra, F. P. J. T. Rutjes and J. Mecinović, Chem. Commun., 2014, 50, 5763 DOI: 10.1039/C4CC01861C

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