The direct arylation of N-substituted-4-hydroxy-2-pyridones with aryl boronic acids has been achieved under palladium catalysis. The mild reaction conditions applied in this method and the use of a conventional catalytic system offer an attractive protocol for the efficient synthesis of a variety of 3-arylated products.
E. E. Anagnostaki, A. D. Fotiadou, V. Demertzidou and A. L. Zografos, Chem. Commun., 2014, 50, 6879 DOI: 10.1039/C4CC02166E
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