Issue 56, 2014
From the journal:

Chemical Communications

Enantioselective synthesis of benzazepinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids†

Xuejian Li,a   Di Chen,a   Haorui Gua  and  Xufeng Lin*a  

* Corresponding authors

a Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China
E-mail: lxfok@zju.edu.cn

Abstract

The first highly enantioselective iso-Pictet–Spengler reaction of C-2-linked o-aminobenzylindoles with trifluoromethyl ketones was developed using chiral spirocyclic phosphoric acids as organocatalysts, which afforded optically active benzazepinoindoles bearing trifluoromethylated quaternary stereocenters.

Graphical abstract: Enantioselective synthesis of benzazepinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids

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Article information

DOI
https://doi.org/10.1039/C4CC02295E
Article type
Communication
Submitted
28 Mar 2014
Accepted
22 May 2014
First published
22 May 2014

Chem. Commun., 2014,50, 7538-7541

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Enantioselective synthesis of benzazepinoindoles bearing trifluoromethylated quaternary stereocenters catalyzed by chiral spirocyclic phosphoric acids

X. Li, D. Chen, H. Gu and X. Lin, Chem. Commun., 2014, 50, 7538 DOI: 10.1039/C4CC02295E

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