Issue 55, 2014
From the journal:

Chemical Communications

Palladium catalyzed, heteroatom-guided C–H functionalization in the synthesis of substituted isoquinolines and dihydroisoquinolines†‡

Virendra Kumar Tiwari,a   Govind Goroba Pawar,a   Himanshu Sekhar Jenaa  and  Manmohan Kapur*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Indore Bypass Road, Bhauri, Bhopal 462066, India
E-mail: mk@iiserb.ac.in
Fax: +91-755-6692 392
Tel: +91-755-6692-324

Abstract

A new approach for the functionalization of C-4 of isoquinolines is reported. The method utilizes palladium catalyzed, hetero-atom guided (or electrophilic metalation) direct arylation via regioselective C–H functionalization of dihydroisoquinolines.

Graphical abstract: Palladium catalyzed, heteroatom-guided C–H functionalization in the synthesis of substituted isoquinolines and dihydroisoquinolines

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Article information

DOI
https://doi.org/10.1039/C4CC03165B
Article type
Communication
Submitted
28 Apr 2014
Accepted
19 May 2014
First published
29 May 2014

Chem. Commun., 2014,50, 7322-7325

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Palladium catalyzed, heteroatom-guided C–H functionalization in the synthesis of substituted isoquinolines and dihydroisoquinolines

V. K. Tiwari, G. G. Pawar, H. S. Jena and M. Kapur, Chem. Commun., 2014, 50, 7322 DOI: 10.1039/C4CC03165B

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