Issue 67, 2014
From the journal:

Chemical Communications

A general metal free approach to α-ketoamides via oxidative amidation–diketonization of terminal alkynes†

Ramesh Deshidi,a   Manjeet Kumar,a   Shekaraiah Devaria  and  Bhahwal Ali Shah*a  

* Corresponding authors

a Academy of Scientific and Innovative Research (AcSIR), Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, India
E-mail: bashah@iiim.res.in

Abstract

A novel catalytic system TMSOTf/I2/DMSO for the oxidative coupling of terminal alkynes with virtually any primary/secondary amine leading to α-ketoamides has been developed. The reaction possibly proceeds via iminium ion formation, wherein DMSO acts as a solvent as well as an oxidizing agent.

Graphical abstract: A general metal free approach to α-ketoamides via oxidative amidation–diketonization of terminal alkynes

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Article information

DOI
https://doi.org/10.1039/C4CC03783A
Article type
Communication
Submitted
19 May 2014
Accepted
11 Jun 2014
First published
12 Jun 2014

Chem. Commun., 2014,50, 9533-9535

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A general metal free approach to α-ketoamides via oxidative amidation–diketonization of terminal alkynes

R. Deshidi, M. Kumar, S. Devari and B. A. Shah, Chem. Commun., 2014, 50, 9533 DOI: 10.1039/C4CC03783A

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