We describe here hitherto unexplored chemistry of the sulfinate ester functional group as being highly selective towards nucleophilic substitution by thiols at physiological pH. Using this cleavable trigger, an optical thiol probe that is suitable for thiol bioimaging has been developed.
S. R. Malwal, A. Labade, A. S. Andhalkar, K. Sengupta and H. Chakrapani, Chem. Commun., 2014, 50, 11533 DOI: 10.1039/C4CC05462H
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