A simple and sustainable tetrabutylammonium fluoride (TBAF)-catalyzed synthesis of azaarene-substituted 3-hydroxy-2-oxindoles through sp3 C–H functionalization

Abstract

A green, practical, and metal-free protocol for direct addition of α-and γ-alkylazaarenes to isatins has been developed via sp³ C–H functionalization in water under controlled microwave radiation. This methodology provides a mild and fast route to biologically important azaarene-substituted 3-hydroxy-2-oxindoles in good to excellent yields.