A class of linker free amphiphilic PEG grafted polymer support for linear and cyclic peptides†
Abstract
PEG grafted (PEG400 and PEG1500), highly hydrophobic/hydrophilic balanced polymeric Schiff base dendron resins were synthesized by the reaction between diethylenetriamine and benzaldehyde molecules and characterized. The usefulness of the resins was demonstrated by synthesizing biologically significant linear as well as disulfide classes of endothelin peptides in high yields and purities.