Mn(OAc)3-mediated synthesis of β-hydroxyphosphonates from P(O)–H compounds and alkenes

Yuzhen Gao; Ju Wu; Jian Xu; Pengbo Zhang; Guo Tang; Yufen Zhao

doi:10.1039/C4RA10593A

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Mn(OAc)₃-mediated synthesis of β-hydroxyphosphonates from P(O)–H compounds and alkenes†

Yuzhen Gao,^a Ju Wu,^a Jian Xu,^a Pengbo Zhang,^a Guo Tang*^a and Yufen Zhao^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China
E-mail: t12g21@xmu.edu.cn
Fax: +86-592-2185780

^b Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China

Abstract

A new and general method for the synthesis of β-hydroxy phosphonates has been achieved through Mn(OAc)₃-mediated radical oxidative phosphonation of alkenes with H-phosphonates and H-phosphine oxide. The starting materials of P(O)–H compounds and alkenes are stable and cheap. Mn(OAc)₃ can be readily prepared from Mn(OAc)₂ in the laboratory. This method can be easily adapted to large-scale preparations.

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Article information

DOI: https://doi.org/10.1039/C4RA10593A
Article type: Communication
Submitted: 17 Sep 2014
Accepted: 06 Oct 2014
First published: 08 Oct 2014

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RSC Adv., 2014,4, 51776-51779

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Mn(OAc)₃-mediated synthesis of β-hydroxyphosphonates from P(O)–H compounds and alkenes

Y. Gao, J. Wu, J. Xu, P. Zhang, G. Tang and Y. Zhao, RSC Adv., 2014, 4, 51776 DOI: 10.1039/C4RA10593A

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