Issue 17, 2015

Analysis of ATP and AMP binding to a DNA aptamer and its imidazole-tethered derivatives by surface plasmon resonance

Abstract

Imidazole was tethered to the C5 position of thymine in an ATP-binding DNA aptamer with two types of linkers, and the affinities of each aptamer for ATP and AMP were determined by surface plasmon resonance measurements. The imidazole-tethered aptamers exhibited higher affinity for ATP, almost independently of the linker structure or the modification site.

Graphical abstract: Analysis of ATP and AMP binding to a DNA aptamer and its imidazole-tethered derivatives by surface plasmon resonance

Supplementary files

Article information

Article type
Communication
Submitted
05 Jul 2015
Accepted
16 Jul 2015
First published
16 Jul 2015

Analyst, 2015,140, 5881-5884

Author version available

Analysis of ATP and AMP binding to a DNA aptamer and its imidazole-tethered derivatives by surface plasmon resonance

J. Zhao, S. Katsube, J. Yamamoto, K. Yamasaki, M. Miyagishi and S. Iwai, Analyst, 2015, 140, 5881 DOI: 10.1039/C5AN01347J

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