Issue 9, 2015
From the journal:

Chemical Communications

One-by-one single-molecule detection of mutated nucleobases by monitoring tunneling current using a DNA tip†

Phuc Tan Bui,a   Tomoaki Nishino,*b   Hiroshi Shiigib  and  Tsutomu Nagaokab  

* Corresponding authors

a Department of Materials Science, Osaka Prefecture University, Sakai, Osaka, Japan

b Department of Applied Chemistry, Osaka Prefecture University, Sakai, Osaka, Japan
E-mail: nishino@chem.osakafu-u.ac.jp
Fax: +81-72-254-8194
Tel: +81-72-254-8194

Abstract

A DNA molecule was utilized as a probe tip to achieve single-molecule genetic diagnoses. Hybridization of the probe and target DNAs resulted in electron tunneling along the emergent double-stranded DNA. Simple stationary monitoring of the tunneling current leads to single-molecule DNA detection and discovery of base mismatches and methylation.

Graphical abstract: One-by-one single-molecule detection of mutated nucleobases by monitoring tunneling current using a DNA tip

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Article information

DOI
https://doi.org/10.1039/C4CC08227C
Article type
Communication
Submitted
17 Oct 2014
Accepted
05 Dec 2014
First published
05 Dec 2014

Chem. Commun., 2015,51, 1666-1669

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One-by-one single-molecule detection of mutated nucleobases by monitoring tunneling current using a DNA tip

P. T. Bui, T. Nishino, H. Shiigi and T. Nagaoka, Chem. Commun., 2015, 51, 1666 DOI: 10.1039/C4CC08227C

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