Copper-catalyzed direct α-ketoesterification of propiophenones with acetophenones via C(sp3)–H oxidative cross-coupling

Juan Du; Xiuli Zhang; Xi Sun; Lei Wang

doi:10.1039/C4CC09524C

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Copper-catalyzed direct α-ketoesterification of propiophenones with acetophenones via C(sp³)–H oxidative cross-coupling†

Juan Du,^a Xiuli Zhang,*^ab Xi Sun^a and Lei Wang*^bc

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* Corresponding authors

^a Department of Chemistry, Anhui Agricultural University, Hefei, Anhui 230036, P. R. China
E-mail: zhxiuli@163.com
Fax: +86-551-65786-121
Tel: +86-551-6578-6791

^b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China

^c Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China
E-mail: leiwang@chnu.edu.cn

Abstract

A novel copper-catalyzed direct α-ketoesterification of propiophenones with acetophenones via C(sp³)–H oxidative cross-coupling was developed. The reaction utilized O₂ as a clean oxidant with high atom economy and the starting materials are facile and commercially available.

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Article information

DOI: https://doi.org/10.1039/C4CC09524C
Article type: Communication
Submitted: 28 Nov 2014
Accepted: 01 Feb 2015
First published: 03 Feb 2015

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Chem. Commun., 2015,51, 4372-4375

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Copper-catalyzed direct α-ketoesterification of propiophenones with acetophenones via C(sp³)–H oxidative cross-coupling

J. Du, X. Zhang, X. Sun and L. Wang, Chem. Commun., 2015, 51, 4372 DOI: 10.1039/C4CC09524C

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