Issue 22, 2015
From the journal:

Chemical Communications

A non-aggregated and tumour-associated macrophage-targeted photosensitiser for photodynamic therapy: a novel zinc(ii) phthalocyanine containing octa-sulphonates†

Xing-Shu Li,a   Mei-Rong Ke,a   Miao-Fen Zhang,a   Qing-Qing Tang,a   Bi-Yuan Zhenga  and  Jian-Dong Huang*a  

* Corresponding authors

a College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou 350116, China
E-mail: jdhuang@fzu.edu.cn

Abstract

A novel zinc(II) phthalocyanine bearing octa-sulphonates has been prepared, which is non-aggregated in water, highly photoactive and low dark-toxic. More interestingly, it exhibits specific affinity to macrophages via the scavenger receptor-A, and can selectively accumulate in tumour sites.

Graphical abstract: A non-aggregated and tumour-associated macrophage-targeted photosensitiser for photodynamic therapy: a novel zinc(ii) phthalocyanine containing octa-sulphonates

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Article information

DOI
https://doi.org/10.1039/C4CC09934F
Article type
Communication
Submitted
12 Dec 2014
Accepted
10 Feb 2015
First published
11 Feb 2015

Chem. Commun., 2015,51, 4704-4707

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A non-aggregated and tumour-associated macrophage-targeted photosensitiser for photodynamic therapy: a novel zinc(II) phthalocyanine containing octa-sulphonates

X. Li, M. Ke, M. Zhang, Q. Tang, B. Zheng and J. Huang, Chem. Commun., 2015, 51, 4704 DOI: 10.1039/C4CC09934F

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