DNA–RNA heteroduplexes have been used as templates for copper nanocluster (CuNC) formation for the first time. Taking advantage of the electrocatalysis of CuNCs, quantitation of miRNA can thus be accomplished. More importantly, by simply operating several rounds of CuNC formation, repeated detection of miRNA has further been realized, which is rare in miRNA biosensors.
Z. Wang, L. Si, J. Bao and Z. Dai, Chem. Commun., 2015, 51, 6305 DOI: 10.1039/C5CC01081K
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