Issue 16, 2015
From the journal:

Dalton Transactions

Enhanced cancer cell killing of a Pt(iv) prodrug promoted by outer-sphere coordination with polyethyleneimines†

A. Garaikoetxea Arguinzoniz,a   N. Gómez Blanco,a   P. Ansorena Legarraa  and  J. C. Mareque-Rivas*ab  

* Corresponding authors

a Theranostic Nanomedicine Laboratory, CIC biomaGUNE, Paseo Miramón 182, San Sebastián, Euskadi, Spain
E-mail: jmareque@cicbiomagune.es
Tel: +34 943 005313

b Ikerbasque, Basque Foundation for Science, Bilbao, Euskadi, Spain

Abstract

The cisplatin prodrug c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CO2)2]2− (1) forms outer-sphere coordination interactions with non-toxic low MW PEI, which results in enhanced cancer cell killing, also achieved using PEI-coated AuNPs.

Graphical abstract: Enhanced cancer cell killing of a Pt(iv) prodrug promoted by outer-sphere coordination with polyethyleneimines

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Article information

DOI
https://doi.org/10.1039/C5DT00175G
Article type
Communication
Submitted
14 Jan 2015
Accepted
12 Mar 2015
First published
13 Mar 2015
This article is Open Access
Creative Commons BY license

Dalton Trans., 2015,44, 7135-7138

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Enhanced cancer cell killing of a Pt(IV) prodrug promoted by outer-sphere coordination with polyethyleneimines

A. Garaikoetxea Arguinzoniz, N. Gómez Blanco, P. Ansorena Legarra and J. C. Mareque-Rivas, Dalton Trans., 2015, 44, 7135 DOI: 10.1039/C5DT00175G

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