A combination of iridium/copper associated with (R)-Difluorphos catalyst for the asymmetric ring opening reaction of azabenzonorbornadienes with amines was developed, which afforded chiral trans-vicinal diamines in 80–97% yields with 93–95% enantioselectivities.
C. Zeng, F. Yang, J. Chen, J. Wang and B. Fan, Org. Biomol. Chem., 2015, 13, 8425 DOI: 10.1039/C5OB01243K
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