Issue 22, 2016

Rational design of hybridization chain reaction monomers for robust signal amplification

Abstract

We established four-point guidelines for the sequence design of hairpin monomers in hybridization chain reaction (HCR). This enabled greater flexibility to customize specific hairpin sequences for use with the readout platform of interest. Using shorter hairpin stem length, a one-pot signal amplification system was demonstrated by incorporating distance-sensitive Förster resonance energy transfer (FRET) readout.

Graphical abstract: Rational design of hybridization chain reaction monomers for robust signal amplification

Supplementary files

Article information

Article type
Communication
Submitted
27 Oct 2015
Accepted
15 Feb 2016
First published
16 Feb 2016

Chem. Commun., 2016,52, 4219-4222

Rational design of hybridization chain reaction monomers for robust signal amplification

Y. S. Ang and L. L. Yung, Chem. Commun., 2016, 52, 4219 DOI: 10.1039/C5CC08907G

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